منابع مشابه
Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation.
Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates ...
متن کاملPolyphosphate modulates blood coagulation and fibrinolysis.
Inorganic polyphosphate is an abundant component of acidocalcisomes of bacteria and unicellular eukaryotes. Human platelet dense granules strongly resemble acidocalcisomes, and we recently showed that they contain substantial amounts of polyphosphate, which is secreted upon platelet activation. We now report that polyphosphate is a potent hemostatic regulator, accelerating blood clotting by act...
متن کاملPlatelets and coagulation in infection
Disseminated intravascular coagulation (DIC) is a frequent complication in sepsis that is associated with worse outcomes and higher mortality in patients. In addition to the uncontrolled generation of thrombi throughout the patient's vasculature, DIC often consumes large quantities of clotting factors leaving the patient susceptible to hemorrhaging. Owing to these complications, patients often ...
متن کاملActivation of platelets and coagulation
Ned Tijdschr Klin Chem Labgeneesk 2016, vol. 41, no. 1
متن کاملCoagulation factor interaction with platelets.
Since the initial observation that bleeding is stopped by a platelet plug, it has been clear that platelets play an important role in hemostasis. Patients with very low platelet counts (thrombocytopenia) or with disfunctional platelets have a bleeding diathesis. With the further observation that the platelet plug becomes interwoven with fibrin, it has become clear that platelets interact with t...
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ژورنال
عنوان ژورنال: International Journal of Laboratory Hematology
سال: 2015
ISSN: 1751-5521
DOI: 10.1111/ijlh.12349